Gelli, H. P., Vazquez-Uribe, R. & Sommer, M. O. A. Screening for effective cell-penetrating peptides with minimal impact on epithelial cells and gut commensals in vitro. Front. Pharmacol. 13, (2022).
Keywords: cell-penetrating peptides, cytotoxicity, permeation enhancer, cell viability, gut microbiota, intestinal absorption, caco-2 cells, in vitro
Published: November 2, 2022
Cegarra, C. et al. An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family. PLOS ONE 17, e0274667 (2022).
Keywords: Antibody Binding Capacity, Blood Brain Barrier, Brain Microvascular Endothelial Cells, Human Cerebral Microvascular Endothelial Cell, Apparent Permeability, Receptor-Mediated Transcytosis, TEER, Trans-Endothelial Electrical Resistance.
Note: PharmaCo-Cell® BBB Kits incorporate cellQART® Cell Culture Inserts
Published: September 15, 2022
Hansen, R. H. et al. Increased Intrathecal Activity of Follicular Helper T Cells in Patients With Relapsing-Remitting Multiple Sclerosis. Neurol. - Neuroimmunol. Neuroinflammation 9, (2022).
Keywords: blood-brain barrier; human brain microvascular endothelial cells; immunoglobulin G; interferon; interleukin; melanoma cell adhesion molecule 1; multiple sclerosis; peripheral blood mononuclear cells; programmed cell death protein 1; TEER; transendothelial electrical resistance
Published: July 14, 2022
Lutz, T. M., Kimna, C. & Lieleg, O. A pH-stable, mucin based nanoparticle system for the co-delivery of hydrophobic and hydrophilic drugs. Int. J. Biol. Macromol. 215, 102–112 (2022).
Keywords: glycoprotein; hesperidin; β-Carotene; swelling; enzymatic degradation tests
Published: June 17, 2022
von Essen, M. R. et al. Ofatumumab Modulates Inflammatory T Cell Responses and Migratory Potential in Patients With Multiple Sclerosis. Neurol. Neuroimmunol. Neuroinflammation 9, e200004 (2022).
Keywords: blood-brain barrier; dendritic cell; human brain microvascular endothelial cell; myelin basic protein; myelin oligodendrocyte glycoprotein; multiple sclerosis; peripheral blood mononuclear cell; transendothelial electrical resistance
Published: June 07, 2022
Dacheux, M. A. et al. Prometastatic Effect of ATX Derived from Alveolar Type II Pneumocytes and B16-F10 Melanoma Cells. Cancers 14, 1586 (2022).
Keywords: autotaxin; lysophosphatidic acid; metastasis; B16-F10; melanoma; alveolar type II cells; tumor microenvironment; tumor immunity
Published: March 21, 2022
Cuanalo-Contreras, K. & Benkmann, D. Towards More Human and Humane Testing: The Role of the Device Supplier Industry. Altern. Lab. Anim. ATLA 2611929211073132 (2022).
Keywords: animal-free; cell culture; cosmetic testing; drug discovery; in vitro; new approach methodologies; supplier industry; toxicology
Published: February 20, 2022
Ngo, T. T. T. et al. Functional differentiation and scalable production of renal proximal tubular epithelial cells from human pluripotent stem cells in a dynamic culture system. Cell Prolif. e13190 (2022).
Keywords: Pluripotent stem cells; alginate; bioreactor; functional tubular epithelial cells; kidney differentiation
Wu, X. et al. Localised light delivery on melanoma cells using optical microneedles. Biomed. Opt. Express 13, 1045–1060 (2022).
Keywords: Light-based therapy; skin cancer; in vitro; B16F10 melanoma cells
Basmaeil, Y. et al. Decidua Parietalis Mesenchymal Stem/Stromal Cells and Their Secretome Diminish the Oncogenic Properties of MDA231 Cells In Vitro. Cells 10, 3493 (2021).
Keywords: placenta; decidua parietalis MSCs; MDA231; conditioned medium; adhesion; proliferation; migration; invasion; angiogenesis
Published: December 10, 2021
Nintou, E. et al. Effects of In Vitro Muscle Contraction on Thermogenic Protein Levels in Co-Cultured Adipocytes. Life Basel Switz. 11, 1227 (2021).
Keywords: EPS; UCP1; adipocytes; muscle contraction; myotubes; thermogenesis
Published: November 12, 2021
Singh, B. et al. Towards More Predictive, Physiological and Animal-free In Vitro Models: Advances in Cell and Tissue Culture 2020 Conference Proceedings. Altern. Lab. Anim. ATLA 49, 93–110 (2021).
Keywords: 3-D; 3Rs; Three Rs; animal replacement; animal-free; in vitro; microphysiological system; new approach methodologies; organ-on-a-chip; organoid; tissue microenvironment
Published: July 6, 2021