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Papers citing cellQART®

Peer-reviewed scientific publications of our users around the globe



Published: February 22, 2024

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Reid, S. E. et al. Cancer-associated fibroblasts rewire the estrogen receptor response in luminal breast cancer, enabling estrogen independence. Oncogene 1–14 (2024) doi:10.1038/s41388-024-02973-x.

Keywords: breast cancer cells; CAF2 cells; co-culture

Published: February 07, 2024

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Freitas-Dias, C. et al. Interaction between NSCLC Cells, CD8+ T-Cells and Immune Checkpoint Inhibitors Potentiates Coagulation and Promotes Metabolic Remodeling—New Cues on CAT-VTE. Cells 13, 305 (2024).

Keywords: cancer-associated thrombosis (CAT); immune checkpoint inhibitors (ICIs); metabolic remodeling; non-small cell lung cancer (NSCLC); tissue factor (TF); venous thromboembolism (VTE); TCD8+; NSCLC; co-culture

Published: January 03, 2024

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Motta, G. et al. An integrated new approach methodology for inhalation risk assessment of safe and sustainable by design nanomaterials. Environ. Int. 183, 108420 (2024).

Keywords: Air liquid interface exposure; co-culture; Cytotoxicity; Human exposure doses; Inflammation; Nanoparticle; New approach methodology; Risk assessment and hazard; Human alveolar epithelial cells A549; human monocytes THP-1

Published: December, 2023

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Thougaard, E., Carney, B., Wlodarczyk, A., Brambilla, R. & Lambertsen, K. L. Peripherally derived myeloid cells induce disease-dependent phenotypic changes in microglia. Front. Cell. Neurosci. 17, 1295840 (2023).

Keywords: ischemic stroke; microglia; multiple sclerosis; myeloid cells; neuroinflammation; co-culture

Published: August 22, 2023

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Fernando, V., Zheng, X., Sharma, V. & Furuta, S. Reprogramming of breast tumor-associated macrophages with modulation of arginine metabolism. BioRxiv Prepr. Serv. Biol. 2023.08.22.554238 (2023) doi:10.1101/2023.08.22.554238.

Keywords: HER2; breast cancer; nitric oxide; polyamines; tetrahydrobiopterin; THP–1 cells; CA1d; SKBR3; BT-474; co-culture

Published: June 26, 2023

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Fetahu, I. S. et al. Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis. Nat. Commun. 14, 3620 (2023).

Keywords: Single-cell transcriptomics; epigenomics; monocytes; neuroblastoma; metastasis

Published: May 31, 2023

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Subayyil, A. A. et al. Preconditioned Chorionic Villus Mesenchymal Stem/Stromal Cells (CVMSCs) Minimize the Invasive Phenotypes of Breast Cancer Cell Line MDA231 In Vitro. Int. J. Mol. Sci. 24, 9569 (2023).

Keywords: HMECs; MDA231; adhesion; chorionic villus MSCs; conditioned media; epithelial to mesenchymal transition (EMT); flow cytometry; flow cytometry; invasion; migration; proliferation

Published: March 31, 2023

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Pop, O.-T. et al. AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells. Cell. Mol. Gastroenterol. Hepatol. 0, (2023).

Keywords: TAM Receptors; Innate Immunity; Cirrhosis; Resident Liver Macrophages

Published: January 01, 2023

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Hameedat, F., Pinto, S., Marques, J., Dias, S. & Sarmento, B. Functionalized zein nanoparticles targeting neonatal Fc receptor to enhance lung absorption of peptides. Drug Deliv. and Transl. Res. 13, 1699–1715 (2023).

Keywords: Peptides delivery; Neonatal Fc receptor; Lung absorption; Targeted nanoparticles; Zein nanoparticles; PEGylation; Permeability assay

Published: December 10, 2021

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Basmaeil, Y. et al. Decidua Parietalis Mesenchymal Stem/Stromal Cells and Their Secretome Diminish the Oncogenic Properties of MDA231 Cells In Vitro. Cells 10 , 3493 (2021).

Keywords: placenta; decidua parietalis MSCs; MDA231; conditioned medium; adhesion; proliferation; migration; invasion; angiogenesis

Published: November 12, 2021

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Nintou, E. et al. Effects of In Vitro Muscle Contraction on Thermogenic Protein Levels in Co-Cultured Adipocytes. Life Basel Switz. 11 , 1227 (2021).

Keywords: EPS; UCP1; adipocytes; muscle contraction; myotubes; thermogenesis


Published: June 17, 2022

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Lutz, T. M., Kimna, C. & Lieleg, O. A pH-stable, mucin based nanoparticle system for the co-delivery of hydrophobic and hydrophilic drugs. Int. J. Biol. Macromol. 215, 102–112 (2022). 

Keywords: glycoprotein; hesperidin; β-Carotene; swelling; enzymatic degradation tests


Published: February 29, 2024

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Buccato, D. G. et al. In Vitro Assessment of Cortisol Release Inhibition, Bioaccessibility and Bioavailability of a Chemically Characterized Scutellaria lateriflora L. Hydroethanolic Extract. Molecules 29, 586 (2024).

Keywords: Scutellaria lateriflora L.; cortisol; stress; bioaccessibility; bioavailability; osteoporosis; Caco-2

Published: February 22, 2024

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Keuter, L. et al. Structural Impact of Steroidal Glycoalkaloids: Barrier Integrity, Permeability, Metabolism, and Uptake in Intestinal Cells. Mol. Nutr. Food Res. n/a, 2300639.

Keywords: Caco-2; HPLC-MS; barrier function; bioavailability; metabolism; steroidal glycoalkaloids

Published: February 21, 2024

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Carone, M. et al. 3D-Printed Lipid Mesophases for the Treatment of Chronic Liver Disease. Adv. Mater. Technol. n/a, 2301930.

Keywords: Caco-2; monolayer integrity assessment

Published: February 15, 2024

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Gleixner, S. et al. Characterization of a new lacrimal gland cell line in 2D and 3D cell culture models. 2024.02.13.580096 Preprint at (2024).

Keywords: Fluorescein isothiocyanate (FITC)-dextran permeability assay; human lacrimal gland epithelial cells

Published: February 13, 2024

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Baqué-Vidal, L. et al. Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells. Cytotherapy S1465-3249(24)00046-X (2024) doi:10.1016/j.jcyt.2024.01.014.

Keywords: age-related macular degeneration; clinical translation; cryopreservation; manufacturing; retinal pigment epithelium

Published: January 22, 2024

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Morath, K. et al. Activation-neutral gene editing of tonsillar CD4 T cells for functional studies in human ex vivo tonsil cultures. Cell Rep. Methods 4, (2024).

Keywords: CP: Biotechnology; CP: Immunology; HIV infection; adaptive immunity; ex vivo human tonsil histoculture; gene editing

Published: January 19, 2024

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Kotze, S., Ebert, A. & Goss, K.-U. Effects of Aqueous Boundary Layers and Paracellular Transport on the Efflux Ratio as a Measure of Active Transport Across Cell Layers. Pharmaceutics 16, 132 (2024).

Keywords: Caco-2; MDCK; P-glycoprotein; active transport; efflux transporters; permeability

Published: January 10, 2024

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Mazhar, S. et al. In vitro safety and functional characterization of the novel Bacillus coagulans strain CGI314. Front. Microbiol. 14, 1302480 (2023).

Keywords: Bacillus coagulans CGI314; antioxidant; functional foods; intestinal-epithelial barrier integrity; probiotic properties

Published: January 10, 2024

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Wang, J., de Bruijn, V., Rietjens, I. M. C. M., Kramer, N. I. & Bouwmeester, H. Use of Physiologically Based Kinetic Modeling to Predict Deoxynivalenol Metabolism and Its Role in Intestinal Inflammation and Bile Acid Kinetics in Humans. J. Agric. Food Chem. 72, 761–772 (2024).

Keywords: bile acid malabsorption; deoxynivalenol; intestinal inflammation; physiologically based kinetic modeling; quantitative in vitro to in vivo extrapolation; Caco-2

Published: December 1, 2023

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Dahley, C., Goss, K.-U. & Ebert, A. Revisiting the pKa-Flux method for determining intrinsic membrane permeability. Eur. J. Pharm. Sci. Off. J. Eur. Fed. Pharm. Sci. 191, 106592 (2023).

Keywords: Aqueous boundary layer; Caco-2; Concentration-shift; MDCK; Passive permeability; pK(a)-Flux method

Published: November 9, 2023

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Liu, L. et al. Impact of Ivermectin on the Gut Microbial Ecosystem. Int. J. Mol. Sci. 24, 16125 (2023).

Keywords: SHIME; gut microbiome; insoluble fiber; ivermectin; short chain fatty acid; soluble fiber; Caco-2 cells

Published: September 29, 2023

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Sarry, M. et al. Development of a primary cell model derived from porcine dorsal soft palate for foot-and-mouth disease virus research and diagnosis. Front. Microbiol. 14, (2023).

Keywords: foot-and-mouth disease virus; cellular model; primary model; primary cells; swine; air-liquid interface multilayers; dorsal soft plate cells

Published: August 03, 2023

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Hendrix, E. et al. A protein hydroxylase couples epithelial membrane biology to nucleolar ribosome biogenesis. 2023.03.15.532818 Preprint at (2023).

Keywords: Caco-2; TEER

Published: June, 2023

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Skúladóttir, S. R. Differentiation of HaCaT skin cells in culture and their potential for studying atopic dermatitis.

Keywords: HaCaT cells; keratinocytes; ALI

Published: May 26, 2023

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Ninaber, D. K., Does, A. M. van der & Hiemstra, P. S. Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures. JoVE J. Vis. Exp. e65102 (2023) doi:10.3791/65102.

Keywords: Bronchial epithelial cells; lung tissue; air-liquid interface

Published: January 26, 2023

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Phimister, F. D. Further development of a cell culture based approach to model the diet-derived impacts on the faecal microbiome and potential host health in the domestic dog.

Keywords: canine intestinal epithelial cells; TEER

Published: November 2, 2022

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Gelli, H. P., Vazquez-Uribe, R. & Sommer, M. O. A. Screening for effective cell-penetrating peptides with minimal impact on epithelial cells and gut commensals in vitro. Front. Pharmacol. 13, (2022).

Keywords: cell-penetrating peptides; cytotoxicity; permeation enhancer; cell viability; gut microbiota; intestinal absorption; caco-2 cells; in vitro

Published: January 31, 2022

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Ngo, T. T. T. et al. Functional differentiation and scalable production of renal proximal tubular epithelial cells from human pluripotent stem cells in a dynamic culture system. Cell Prolif. e13190 (2022).

Keywords: Pluripotent stem cells; alginate; bioreactor; functional tubular epithelial cells; kidney differentiation


Published: February 27, 2024

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Cai, Z. et al. Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through α-ketoglutarate and mTORC1 signaling. Cell. Mol. Immunol. (2024) doi:10.1038/s41423-024-01134-0.

Keywords: PHGDH; de novo serine synthesis; mTORC1; protumorigenic; tumor-associated macrophages; metabolomics; α-ketoglutarate; macrophage migration assay

Published: January 11, 2024

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Schirmer, U. et al. Sclerostin Alters Tumor Cell Characteristics of Oral Squamous Cell Carcinoma and May Be a Key Player in Local Bone Invasion. Cells 13, 137 (2024).

Keywords: SOST; bone invasion; oral squamous cell carcinoma; sclerostin; migration assay; invasion assay; PCI-13 cells

Published: September 12, 2023

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Brychka, D. et al. Targeting Monocytic Occludin Impairs Monocyte Transmigration and HIV Neuroinvasion. (2023) doi:10.1101/2023.09.11.557242.

Keywords: Migration assay; hCMEC/D3 cells; primary monocytes; THP-1 cells

Published: June 01, 2023

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Monittola, F. et al. Gastric cancer cell types display distinct proteasome/immunoproteasome patterns associated with migration and resistance to proteasome inhibitors. J. Cancer Res. Clin. Oncol. (2023).

Keywords: Proteasome; Immunoproteasome; Gastric cancer; Cell migration; Proteasome inhibitiors; 20S regulatory particles

Published: January 20, 2023

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Moran, J. et al. Investigating the Effects of Olaparib on the Susceptibility of Glioblastoma Multiforme Tumour Cells to Natural Killer Cell-Mediated Responses. Pharmaceutics 15, 360 (2023).  

Keywords: NK cells; Glioblastoma multiforme; immunotherapy; Olaparib; PARP Inhibitor

Published: December 27, 2022

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Taffoni, C. et al. DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma. The EMBO Journal 42, e111961 (2023).

Keywords: cGAS; DNA-PK; inflammation; tumor immunogenicity

Published: March 21, 2022

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Dacheux, M. A. et al. Prometastatic Effect of ATX Derived from Alveolar Type II Pneumocytes and B16-F10 Melanoma Cells. Cancers 14, 1586 (2022).

Keywords: autotaxin; lysophosphatidic acid; metastasis; B16-F10; melanoma; alveolar type II cells; tumor microenvironment; tumor immunity


Published: February 17, 2024

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Burchett, A. A., Siri, S., Li, J., Lu, X. & Datta, M. Novel 3-D macrophage spheroid model reveals reciprocal regulation of immunomechanical stress and mechano-immunological response. BioRxiv Prepr. Serv. Biol. 2024.02.14.580327 (2024) doi:10.1101/2024.02.14.580327.

Keywords: inflammation; microenvironment; myeloid cells; polarization; solid stress; spheroid; macrophage

Published: January 06, 2024

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García-Rodríguez, I. et al. Assessment of the broad-spectrum host targeting antiviral efficacy of halofuginone hydrobromide in human airway, intestinal and brain organotypic models. Antiviral Res. 222, 105798 (2024).

Keywords: Antiviral; EV-A71; HAE; HCMV; HIE; Halofuginone; Influenza A; PeV-A1; Rhinovirus; SARS-CoV-2; Zika; human fetal intestinal epithelium

Published: April 03, 2023

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Li, P. et al. Mpox virus infects and injures human kidney organoids, but responding to antiviral treatment. Cell Discov. 9, 1–4 (2023).

Keywords: Kidney organoids; monkey pox virus; infection; antiviral

Published: March 27, 2023

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Schumacher, A., Joris, V., van Griensven, M. & LaPointe, V. Ultrastructural comparison of human kidney organoids and human fetal kidneys reveals features of hyperglycemic cultur. Preprint at (2023).

Keywords: Induced pluripotent stem cell (iPSC)–derived kidney organoids; organoid culture


Published: March 12, 2024

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Partiot, E. et al. Organotypic culture of human brain explants as a preclinical model for AI-driven antiviral studies. EMBO Mol Med. (2024).

Keywords: Neurotropic Virus; Bunyavirus; Artificial Intelligence; SmallMolecule; Tahyna Virus; Human Brain Explant Organotypic Culture


Published: February 22, 2024

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Vágvölgyi, M. et al. 17-Oxime ethers of oxidized ecdysteroid derivatives modulate oxidative stress in human brain endothelial cells and dose-dependently might protect or damage the blood-brain barrier. PloS One 19, e0290526 (2024).

Keywords: hCMEC/D3 human brain microvascular endothelial cell; blood-brain barrier; permeability assay

Published: December 30, 2023

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Porkoláb, G. et al. Synergistic induction of blood-brain barrier properties. 2023.02.09.527899 Preprint at (2023).

Keywords: human brain-like ECs; brain pericytes; blood-brain barrier

Published: October 24, 2023

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Younes, H. et al. Effects of Prokineticins on Cerebral Cell Function and Blood–Brain Barrier Permeability. Int. J. Mol. Sci. 24, 15428 (2023).

Keywords: prokineticin; prokineticin receptor; receptors antagonists; blood–brain barrier integrity; brain endothelial cells

Published: April 26, 2023

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Phan, T. H. et al. Advanced pathophysiology mimicking lung models for accelerated drug discovery. Biomaterials Research 27, 35 (2023). 

Keywords: Lung-mimicking models; Multimodal characterisation; Physiological relevance; Microcirculation; Extracellular matrix; Patient-derived cell lines; Personalised medicine

Published: January 26, 2023

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Nakamura, T. et al. Aß42 treatment of the brain side reduced the level of flotillin from endothelial cells on the blood side via FGF-2 signaling in a blood-brain barrier model. Mol Brain 16, 15 (2023).

Keywords: Alzheimer´s disease; Amyloid ß-protein; Blood flotillin; Microvascular endothelial cells

Published: September 15, 2022

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Cegarra, C. et al. An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family. PLOS ONE 17, e0274667 (2022).

Keywords: antibody binding capacity; blood brain barrier; brain microvascular endothelial cells; human cerebral microvascular endothelial cell; apparent permeability; receptor-mediated transcytosis; teer; trans-endothelial electrical resistance

Note: PharmaCo-Cell® BBB Kits incorporate cellQART® Cell Culture Inserts

Published: July 14, 2022

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Hansen, R. H. et al. Increased Intrathecal Activity of Follicular Helper T Cells in Patients With Relapsing-Remitting Multiple Sclerosis. Neurol. - Neuroimmunol. Neuroinflammation 9, (2022).

Keywords: blood-brain barrier; human brain microvascular endothelial cells; immunoglobulin G; interferon; interleukin; melanoma cell adhesion molecule 1; multiple sclerosis; peripheral blood mononuclear cells; programmed cell death protein 1; TEER; transendothelial electrical resistance

Published: June 07, 2022

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von Essen, M. R. et al. Ofatumumab Modulates Inflammatory T Cell Responses and Migratory Potential in Patients With Multiple Sclerosis. Neurol. Neuroimmunol. Neuroinflammation 9, e200004, (2022).

Keywords: blood-brain barrier; dendritic cell; human brain microvascular endothelial cell; myelin basic protein; myelin oligodendrocyte glycoprotein; multiple sclerosis; peripheral blood mononuclear cell; transendothelial electrical resistance


Published: July 18, 2023

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Cuanalo-Contreras, K., Hogrebe, A. M. R., Teichmann, K. & Benkmann, D. Track-Etched Membranes for Drug Pharmaceutical Research. Chem. Ing. Tech. 95, 1372-1380(2023).

Keywords: drug development; organs-on-a-chip; tissue engineering; toxicology; track-etched membranes

Published: February 20, 2022

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Cuanalo-Contreras, K. & Benkmann, D. et al. Towards More Human and Humane Testing: The Role of the Device Supplier Industry. Altern. Lab. Anim. ATLA 2611929211073132 (2022).

Keywords: animal-free; cell culture; cosmetic testing; drug discovery; in vitro; new approach methodologies; supplier industry; toxicology

Published: January 31, 2022

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Wu, X. et al. Localised light delivery on melanoma cells using optical microneedles. Biomed. Opt. Express 13 , 1045–1060 (2022).

Keywords: light-based therapy; skin cancer; in vitro; B16F10 melanoma cells

Published: January 19, 2022

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Polesca, C., Passos, H., M. Neves, B., P. Countinho, J. A. & G. Freire, M. Valorization of chicken feathers using aqueous solutions of iconic liquids. Green Chemistry 25, 1424-1434(2023).

Keywords: Keratin film; monocytes; macrophages; keratinocytes; fibroblasts

Published: July 6, 2021

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Singh, B. et al. Towards More Predictive, Physiological and Animal-free In Vitro Models: Advances in Cell and Tissue Culture 2020 Conference Proceedings. Altern. Lab. Anim. ATLA 49 , 93–110 (2021).

Keywords: 3-D; 3Rs; Three Rs; animal replacement; animal-free; in vitro; microphysiological system; new approach methodologies; organ-on-a-chip; organoid; tissue microenvironment