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In this paper, von Essen et al. examined the derivative effects of Ofatumumab in B cell depletion on the peripheral immune system and a direct treatment effect on T cells expressing CD20 in Multiple Sclerosis.

Our cellQART 3 micron pore size inserts were used to build a blood brain barrier model containing human brain astrocytes and human brain microvascular endothelial cells to perform transmigration assays under induced inflammatory conditions. For more information check out the link in the comments and visit our cellQART Academy.

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Source: von Essen, M. R. et al. Ofatumumab Modulates Inflammatory T Cell Responses and Migratory Potential in Patients With Multiple Sclerosis. Neurol. Neuroimmunol. Neuroinflammation 9, e200004, (2022).